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23andMe · 9 categories · 157 findings
Top Actions
18 findings · 18 genes tracked
Key finding: Reduced beta-carotene to vitamin A conversion
You carry two copies of the T variant (267S) in the BCMO1 gene, which encodes the primary enzyme that converts beta-carotene into retinal (a form of vitamin A).
💡 Action: Include preformed vitamin A sources (eggs, dairy, liver, fatty fish) in your diet rather than relying solely on beta-carotene from plant foods.
You carry two copies of the T allele (Val16) in SOD2, which encodes manganese superoxide dismutase — the primary antioxidant defense inside mitochondria.
💡 Action: Emphasize antioxidant-rich foods (berries, leafy greens, nuts, seeds) and adequate manganese intake (whole grains, nuts, legumes).
You carry two copies of the C allele (Ala736) at TMPRSS6 rs855791.
💡 Action: Ensure adequate dietary iron from both heme (red meat, poultry) and non-heme sources (legumes, fortified cereals).
You carry two copies of the T allele (Thr235) in AGT, which encodes angiotensinogen — the precursor to angiotensin II, a potent vasoconstrictor.
💡 Action: Monitor your sodium intake and aim for the recommended limit of 2,300mg/day or less.
You carry two copies of the G allele at the VKORC1 promoter variant (-1639G>A).
💡 Action: Standard dietary vitamin K intake through green leafy vegetables is appropriate.
17 findings · 17 genes tracked
Key finding: AGT Thr235 — higher angiotensinogen and BP risk
You carry two T alleles (Thr235Thr) at AGT rs699, associated with approximately 20% higher circulating angiotensinogen levels.
💡 Action: Regular aerobic exercise is especially beneficial for blood pressure management at your genotype.
You carry two copies of the G allele at IL6 -174, associated with higher interleukin-6 production.
💡 Action: Pay attention to recovery between intense sessions.
You carry two copies of the T allele at GDF5 rs143383, associated with reduced GDF5 (growth differentiation factor 5) expression.
💡 Action: Protect your joints: maintain a healthy weight, include low-impact cross-training, strengthen muscles around major joints, and avoid excessive high-impact activities.
You carry two A alleles at MMP3 rs679620, associated with higher matrix metalloproteinase-3 (stromelysin-1) production.
💡 Action: Be mindful of gradual load progression in running and jumping activities.
You carry two C alleles at CRP rs1205, associated with higher baseline C-reactive protein levels.
💡 Action: Monitor your recovery and fatigue levels.
17 findings · 16 genes tracked
Key finding: Typical TNF-alpha levels — lower inflammation-related sleep risk
You carry the GG genotype at TNF rs1800629 (-308G/A).
💡 Action: Your TNF genetics do not independently elevate sleep apnea risk.
You carry the common CC genotype at PER2 rs2304672.
💡 Action: This genotype does not indicate atypical circadian timing.
You carry the common CC genotype at PER3 rs228697, which tags the 4-repeat allele of the PER3 variable-number tandem repeat (VNTR).
💡 Action: You may tolerate occasional short sleep better than average, but consistent 7-9 hours remains recommended for long-term health..
You carry the common CC genotype at ADA rs73598374 (Asp8Asp).
💡 Action: Your adenosine metabolism is typical.
You carry the common GG genotype at MEIS1 rs2300478.
💡 Action: Your MEIS1 genotype does not elevate RLS risk.
19 findings · 20 genes tracked
Key finding: OVOL1 risk genotype — increased eczema susceptibility
You carry two copies of the G allele at OVOL1 rs479844, identified as a risk allele for atopic dermatitis in large GWAS.
💡 Action: Maintain a consistent skin barrier care routine: moisturize regularly, use gentle skincare products, and minimize irritant exposure to reduce eczema risk..
You carry two copies of the common G allele at COL1A1 rs1800012 (the Sp1 binding site polymorphism in the first intron).
💡 Action: Your collagen genetics at this locus are typical.
You carry two copies of the common allele at IRF4 rs12203592.
💡 Action: Standard sun protection measures are appropriate based on this variant..
You carry two copies of the derived C allele (Leu374) at SLC45A2.
💡 Action: Lighter skin pigmentation means less natural UV protection.
You carry two copies of the derived A allele (Thr111) at SLC24A5.
💡 Action: This is a very common European variant.
12 findings · 12 genes tracked
Key finding: Normal aldehyde dehydrogenase activity
You carry two copies of the functional Glu504 allele (G allele) in ALDH2, which encodes mitochondrial aldehyde dehydrogenase 2 — the enzyme primarily responsible for metabolizing acetaldehyde, a toxic intermediate of alcohol breakdown.
💡 Action: Normal ALDH2 activity does not mean alcohol is risk-free.
You carry two copies of the Ile191 allele (C allele) at TAS1R2, a gene encoding one subunit of the sweet taste receptor heterodimer (TAS1R2/TAS1R3).
💡 Action: Your sweet taste perception is in the typical range.
You carry two copies of the Thr110 allele (C allele) in SLC2A2, which encodes the GLUT2 glucose transporter expressed in the intestine, liver, pancreas, and brain.
💡 Action: Your genotype is associated with typical sugar-sensing patterns.
You carry two copies of the common allele (G) at rs34160967 in TAS1R1, which encodes one subunit of the umami (savory) taste receptor.
💡 Action: Your umami taste perception is typical.
You carry two copies of the common C allele at rs307355 in the promoter region of TAS1R3, which encodes the shared subunit of both the sweet (TAS1R2/TAS1R3) and umami (TAS1R1/TAS1R3) taste receptors.
💡 Action: Your TAS1R3 promoter genotype is common and associated with typical sweet/umami receptor expression.
18 findings · 18 genes tracked
Key finding: Normal warfarin dose requirement at VKORC1
You carry the GG genotype at the VKORC1 -1639G>A locus, associated with normal VKORC1 expression and a standard warfarin dose requirement.
💡 Action: If prescribed warfarin, your VKORC1 genotype suggests a typical-to-higher dose requirement, but CYP2C9 status and clinical factors also matter.
You are homozygous for the Val158 allele of COMT, giving you roughly 3–4 times higher enzyme activity than Met/Met individuals.
💡 Action: This genotype may be relevant to psychiatric medication selection and pain management approaches.
You do not carry the CYP2C19*17 gain-of-function promoter variant.
💡 Action: Standard dosing of SSRIs and PPIs is generally appropriate at this locus.
You do not carry the variant at rs1065852, which contributes to the CYP2D6*4 haplotype in Europeans and defines the *10 allele common in East Asians.
💡 Action: Normal CYP2D6 function expected at this locus.
You carry the common AA genotype at the OPRM1 Asn40Asp locus, encoding the asparagine (Asn) amino acid at position 40 of the mu-opioid receptor.
💡 Action: Standard opioid dosing protocols apply.
13 findings · 13 genes tracked
Key finding: Two MC1R red hair alleles — likely red hair phenotype
You carry two copies of the MC1R R151C variant, which strongly predicts red hair, very fair skin, and abundant freckling.
💡 Action: This is an ancestry-informative marker strongly associated with Northern/Western European (especially Celtic) ancestry.
You carry two copies of the functional ALDH2*1 allele, which produces a fully active aldehyde dehydrogenase 2 enzyme.
💡 Action: This is an ancestry-informative marker.
You carry two copies of the ancestral C allele (Phe374) at SLC45A2, the original human state.
💡 Action: This is an ancestry-informative marker consistent with sub-Saharan African, East Asian, Southeast Asian, or Indigenous American ancestry..
You carry two copies of the derived A allele (Thr111), which is associated with substantially lighter skin pigmentation.
💡 Action: This is an ancestry-informative marker consistent with European, South Asian, Middle Eastern, or North African ancestry.
You carry two copies of the derived G allele in the HERC2 gene, which acts as a regulatory switch reducing expression of the nearby OCA2 pigmentation gene in the iris.
💡 Action: This is an ancestry-informative marker strongly associated with Northern European ancestry.
17 findings · 17 genes tracked
Key finding: Higher serotonin 2A receptor expression
You carry two G alleles at the HTR2A promoter variant rs6311.
💡 Action: This is a normal variant.
You carry two copies of the Val allele (Val/Val) at COMT Val158Met.
💡 Action: Your cognition may actually improve under moderate stress.
You carry no copies of the Taq1A A1 allele (A2/A2 genotype).
💡 Action: Your dopamine reward circuitry is typical.
You carry two copies of the T allele in the DRD4 promoter region.
💡 Action: This is a normal variant.
You carry two G alleles at rs4570625 in TPH2, the rate-limiting enzyme for serotonin synthesis in the brain.
💡 Action: No specific action is needed.
26 findings · 26 genes tracked
Key finding: Higher IL-6 expression genotype
You carry the GG genotype at IL6 rs1800795 (-174G/C), which is associated with higher IL-6 cytokine production.
💡 Action: Consider anti-inflammatory lifestyle practices: regular exercise, omega-3 rich diet, adequate sleep, and stress management.
You carry the CC genotype at CRP rs1205, associated with higher baseline C-reactive protein levels.
💡 Action: Consider periodic hs-CRP testing as part of cardiovascular risk assessment.
You carry the CC genotype at PPARG rs1801282 (Pro12Ala), meaning you have the Pro/Pro version.
💡 Action: A typical result.
You carry the CC genotype at SLC30A8 rs13266634 (R325W), encoding the arginine (R325) version.
💡 Action: A typical result.
You carry the GG genotype at TNF rs1800629 (-308G/A), the most common genotype (~73% of Europeans).
💡 Action: A typical result.
Include preformed vitamin A sources (eggs, dairy, liver, fatty fish) in your diet rather than relying solely on beta-carotene from plant foods. Pair carotenoid-rich foods with dietary fat to enhance absorption.
From: Reduced beta-carotene to vitamin A conversion
Emphasize antioxidant-rich foods (berries, leafy greens, nuts, seeds) and adequate manganese intake (whole grains, nuts, legumes). Minimize excessive oxidative stressors like smoking and heavy alcohol use.
From: Reduced mitochondrial antioxidant enzyme import
Ensure adequate dietary iron from both heme (red meat, poultry) and non-heme sources (legumes, fortified cereals). Pair non-heme iron with vitamin C to enhance absorption. Consider having your iron levels checked if you experience fatigue or other symptoms. Consult your healthcare provider if concerned.
From: Lower iron and hemoglobin levels
Monitor your sodium intake and aim for the recommended limit of 2,300mg/day or less. Emphasize potassium-rich foods (bananas, potatoes, leafy greens) to help counterbalance sodium's effects. Have your blood pressure checked regularly. Consult your healthcare provider for personalized guidance.
From: Higher angiotensinogen and salt sensitivity
Regular aerobic exercise is especially beneficial for blood pressure management at your genotype. Monitor your blood pressure, moderate sodium intake, and discuss cardiovascular health with your healthcare provider, particularly if you have a family history of hypertension.
From: AGT Thr235 — higher angiotensinogen and BP risk
Pay attention to recovery between intense sessions. Anti-inflammatory nutrition (omega-3s, colorful fruits and vegetables) and adequate sleep may help manage inflammation.
From: Higher IL-6 response — stronger inflammatory signaling
Protect your joints: maintain a healthy weight, include low-impact cross-training, strengthen muscles around major joints, and avoid excessive high-impact activities. Consult your healthcare provider if you develop persistent joint pain.
From: Reduced GDF5 — elevated joint injury risk
Be mindful of gradual load progression in running and jumping activities. Eccentric strengthening exercises may help maintain tendon structural integrity.
From: Higher MMP3 activity — increased tendon remodeling
Monitor your recovery and fatigue levels. Regular moderate exercise actually lowers CRP over time. A diet rich in anti-inflammatory foods (fatty fish, vegetables, whole grains) may help keep baseline CRP in check.
From: Higher baseline CRP — stronger inflammatory marker
Include tendon-conditioning exercises (heavy slow resistance, eccentric loading) in your program, especially if you participate in running or jumping sports.
From: TNC variant — possible tendon injury susceptibility
Consider anti-inflammatory lifestyle practices: regular exercise, omega-3 rich diet, adequate sleep, and stress management. If you have inflammatory conditions, discuss monitoring IL-6 or CRP levels with your healthcare provider.
From: Higher IL-6 expression genotype
Consider periodic hs-CRP testing as part of cardiovascular risk assessment. Anti-inflammatory lifestyle factors — regular exercise, healthy weight, omega-3 intake, and stress management — can help lower CRP levels regardless of genotype.
From: Higher baseline CRP levels genotype
This is an ancestry-informative marker strongly associated with Northern/Western European (especially Celtic) ancestry. Two MC1R loss-of-function variants are associated with increased melanoma risk independent of UV exposure. Practice diligent sun protection and regular skin checks. Consult your healthcare provider about appropriate melanoma screening.
From: Two MC1R red hair alleles — likely red hair phenotype
Maintain a consistent skin barrier care routine: moisturize regularly, use gentle skincare products, and minimize irritant exposure to reduce eczema risk.
From: OVOL1 risk genotype — increased eczema susceptibility
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